Hoʻolālā waiwai maka hou

Molecular hui-hui

--he kemika ʻōmaʻomaʻo mua me ka ʻole o ka uhaki ʻana a me ka hoʻohui hou ʻana

ʻO ke kumu kumu o ka hui ʻana iho o ka molecular:

1. Hoʻomeamea like - hoʻokele i nā mea like e hōʻiliʻili a hoʻonohonoho kekahi i kekahi, a me nā mea me nā waiwai hoʻohui e huki kekahi i kekahi.

2. ʻO ka ikehu haʻahaʻa loa—ʻo ka neʻe ʻana o nā mea a me nā ʻano molekalale e hele i ke kūlana paʻa loa. He ala ia e hoʻonohonoho ʻia ai nā pūʻulu molekula i nā hale kiʻekiʻe.

Molecular self-assembly-designability, hiki i ka hoʻolālā CP ma waena o nā molekala ke hoʻomaikaʻi nui i ka hana biological:

1. Loaʻa i kēlā me kēia mole kona hoʻolālā kūʻokoʻa a me nā waiwai hana, a he paʻakikī ke hoʻokō i ka synergy a me ka hoʻomaʻamaʻa pololei ʻana ma muli o ka hui manuahi ma ka pae hoʻokumu.

2. He nui na mole me ka hana olaola maikai loa i kaupalena nui i ko lakou komo ana a me ka hoohana ana ma muli o ko lakou mau ano ino.

3. ʻO nā mea ikaika o ka lāʻau lapaʻau Kina kahiko e pili ana i "ke mōʻī, nā kuhina a me nā kōkua", ma mua o ka hodgepodge o ka ʻoi aku ka maikaʻi.

ʻO ka hoʻololi ʻana o ka hoʻolālā supramolecular a me ka hoʻohālikelike ʻana i ke kaʻina hana loiloi loiloi:

1. Kākoʻo lolouila kiʻekiʻe-throughput kānana no ka hoʻopaʻa wikiwiki ʻana i nā precursors kūpono mai ka Cambridge Crystal Data Center.

2. E hoʻohana i ka manaʻo hana hoʻopaʻa haʻahaʻa e aʻo ai i ke ʻano supramolecular a me nā waiwai hui i hoʻoholo ʻia e nā pūʻali intermolecular, a e hoʻoholo i ke ʻano supramolecular ka au hoʻokumu.

3. Ma ke kālailai ʻana i nā kūlana pane a me ka paʻakikī, ua ʻoi aku ka maikaʻi o ka hoʻolālā supramolecular.

4. Ka helu ʻana i nā waiwai like ʻole o nā supramolekula, me nā waiwai uila, optical a me thermodynamic.

5. Ka helu ʻana i nā waiwai kikoʻī e like me ka spectrum molecular a me ka spectrum ikehu.

6. Ma o ka ʻenehana docking molecular, ua wānana ʻia nā kahua pili ma waena o nā mea waiwai supramolecular a me nā protein target, a ua wehewehe hohonu ʻia ke ʻano hana ma waena o nā molekala.

Supramolecular eutectic/Ionic paʻakai ʻenehana

ʻO nā hiʻohiʻona ʻenehana: ʻo ka ʻoihana mua, ka nānā ʻana i nā ʻāpana CP maikaʻi loa o nā mea hana no ka hoʻoikaika eutectic

Pōmaikaʻi: hōʻemi i ka huhū, hoʻonui i ka solubility, hoʻomaikaʻi i ka hana, hoʻoikaika i ka permeability, hoʻomaikaʻi i ka paʻa

Nā laʻana o nā mea ʻai: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK

ʻO nā mea hana kūlohelohe i lawe ʻia mai ka papa inoa o nā mea hoʻonaninani maka, ma hope o nā hōʻoia hōʻoia e like me ka quantum chemical simulation, kiʻekiʻe-throughput screening, Gaussian optimization, KingDraw, MestReNova, FTIR, a me NMR, nā huahana i loaʻa he ʻekolu-dimensional crystal structure maikaʻi loa, kūpaʻa maikaʻi, Maʻemaʻe kiʻekiʻe, emi nā haumia. Hiki iā ia ke hoʻoponopono pono i nā wahi ʻeha noiʻi o nā mea hana i ka meaʻai, ka lāʻau lapaʻau a me nā mea hoʻonaninani, a hoʻomaikaʻi i ka bioavailability a me ka palekana o nā mea hana.

ʻenehana hoʻoheheʻe hana supramolecular

nā hiʻohiʻona echnical: ʻO ka ʻoihana mua, ka hui pū ʻana o ka ʻenehana imprinting molecular a me nā mea hoʻoheheʻe supramolecular kūlohelohe, ka unuhi ʻana o nā mea kanu mea kanu.

Nā Pōmaikaʻi: Hoʻonui ʻia ka hoʻoneʻe ʻana, hoʻonui ʻia ka maikaʻi o ka unuhi ʻana e 5 mau manawa i hoʻohālikelike ʻia me ka ʻili ʻana i ka waiʻona, a hoʻonui ʻia ka ʻili wai e 20 mau manawa; ʻaʻohe kaʻawale, hoʻemi ʻia ke kumu kūʻai, nā mea hoʻoikaika i ka komo ʻana Nā Laʻana: ʻoliva (oleuropein, hydroxytyrosol), rhodiola, Phyloporus lāʻau lapaʻau, lilia wai keʻokeʻo, micrococcus

Natural deep eutectic solvent (NaDES): Ua ʻike mua ʻia e nā ʻepekema i ka nānā ʻana i nā metabolomics mea kanu. I ka wā o ka hoʻomohala ʻana o nā mea kanu (germination, cryopreservation), e hoʻokumu ʻia nā cell i kahi wai kūʻokoʻa kūʻokoʻa i ka wai a me nā lipids, e like me ka hui ʻana o nā eutectics.

Ma muli o ka ʻenehana hoʻokaʻawale ʻōmaʻomaʻo hou, ʻenehana membrane i hoʻohui ʻia, hoʻokō ʻia e ka ʻenehana hoʻonui ultrasonic / microwave e hoʻokō i ka haʻahaʻa haʻahaʻa, i hoʻopaʻa ʻia, kiʻekiʻe ciency, kiʻekiʻe kiʻekiʻe a me ka ʻōmaʻomaʻo extraction o nā mea hana. ʻO ka mea hoʻoheheʻe supramolecular i koho ʻia he hana paʻa a hoʻonui i ka solubility o nā mea hana, a hiki ke hoʻonui ʻia ka hoʻonui ʻana i nā manawa he 20.

Supramolecular synergistic penetration technology

Nā hiʻohiʻona ʻenehana: ʻO ka ʻoihana mua, ma o ka mea hoʻoheheʻe supramolecular synergistically hoʻoikaika i ke komo ʻana o nā macromolecules/wai-soluble/paʻakikī ke komo i nā mea ʻai.

ʻO nā pono ʻenehana: hoʻomaikaʻi i ka kūpaʻa, ka hoʻonui ʻole ʻana a me ka hoʻomaikaʻi ʻana i ke komo ʻana, ka hopena synergistic, ka hoʻonui ʻana i ka kuhikuhi i ka dermis, a me ka bioavailability i hoʻonui ʻia e 5-7 mau manawa Mea hoʻohālike: collagen, Bosein, blue copper peptide, hexapeptide, compound peptide , β-glucan.

No ka mea ʻoi aku ka nui o ke kaumaha o ka peptide i hoʻohālikelike ʻia me nā mea hana ʻē aʻe, ua haʻahaʻa ke komo ʻana o ka ʻili. Pono kekahi mau ala e hoʻonui ai i ke komo ʻana e hoʻomaikaʻi i ka hopena absorption hoʻonui i ka peptide, i mea e hoʻokō ai i ka haʻahaʻa haʻahaʻa a me ke kiʻekiʻe efficacy, a loaʻa i ka maikaʻi anti-kahiko.

I ka pane ʻana i ka ʻoihana ʻeha o ke komo ʻana, hydrophilicity kiʻekiʻe a me ka bioavailability haʻahaʻa o nā macromolecules kuʻuna, ʻo ka JUNAS Time Particle huahana synthesis ma o quantum chemistry i kōkua ʻia, hiki ke hele pololei i ka epidermis a me nā dermis o ka ʻili ma o trans-cellular, intercellular a me follicular sweat ductchannels. Me ka ʻole o ka hōʻino ʻana i ka ʻili.

ʻenehana biocatalysis supramolecular

Bioenzyme-directed catalysis: hoʻohana ʻia nā mea hoʻoheheʻe supramolecular ma ke ʻano he substrate e hoʻomaikaʻi ai i ka hana enzyme, hoʻomaikaʻi i ke koho chiral, a loaʻa ka maʻemaʻe kiʻekiʻe.

ʻEnekinia fennel green fermentation: koho i nā mea kanu ʻano, hoʻomaikaʻi i ka ʻike o nā mea hana, anhydrous formula, hoʻomaikaʻi i ka pono holoʻokoʻa

Hoʻihoʻi i ka ʻenehana fermentation micellar: ke nānā ʻana i nā ʻano ʻano ʻano, ka ʻaila ʻaila fermenting, nā hopena hou aku, hoʻomaikaʻi i ka ʻili a me ka hoʻonui ʻana i ka absorption.

Ma muli o ka ʻenehana gene recombinant, hoʻokahi ʻanuʻu gene cloning ʻenehana a me ka bioenzyme catalytic ʻenehana kiʻekiʻe, hoʻohana ʻia nā bacteria genetically engineered ma ke ʻano he catalytic carriers e ʻike ai i ka hana nui o nā mea hana.

Ma lalo o ka ʻōnaehana hoʻoheheʻe supramolecular, hōʻike ka enzyme i ka hana kiʻekiʻe, ke koho a me ke kūpaʻa, ka hoʻohana kiʻekiʻe o nā mea waiwai substrate, ka liʻiliʻi o ka pollution i ke kaʻina hana, nā kūlana haʻahaʻa haʻahaʻa, ka hana palekana kiʻekiʻe a me ka hana hana.

Hoʻololi i ka ʻenehana fermentation micelle:

ʻO nā aila kūlohelohe i koho ʻia me nā ʻano Kina lP ua hoʻolālā ʻia e hana i nā surfactants ma lalo o ka hana a genetically engineered bacteria.lt ua ʻākoakoa ʻia ma ke ʻano he mea lawe i ka puʻupuʻu anti-micellar e ʻike ai i ka puʻupuʻu anti-micellar i hoʻopili ʻia o nā mea hoʻoheheʻe wai e hoʻokō i nā hiʻohiʻona noiʻi waiwai, ʻike hope loa, a me ka maikaʻi maikaʻi, ka ʻike, a me ka pono nui.

ʻenehana microencapsulation supramolecular

Nā hiʻohiʻona ʻenehana: liposome encapsulation, hoʻokuʻu ʻia o nā cell dermal, hoʻokuʻu ʻia o nā follicles lauoho, a me ka hoʻokuʻu pane ʻana o nā mea inflammatory.

Pōmaikaʻi: Nanoization, hāʻawi pololei, hoʻokuʻu hoʻomau lōʻihi, hoʻemi i ka huhū, hoʻomaikaʻi i ke kūpaʻa, a me ka hoʻoikaika ʻana i ka permeability.

Nā laʻana o nā mea ʻai: astaxanthin, glabridin, ka huaʻa A, ka peptide keleawe uliuli, ka biotin, ka ceramide, ka ʻaila koʻikoʻi o nā mea kanu

Supramolecular microencapsulation 'enehana ma luna o liposome, momona emulsion, ionic wai stabilization 'enehana, dermal keena hoʻokuʻu 'enehana, lauoho follicle i hoʻokuʻu 'enehana, a me ka inflammatory mea pane pane 'enehana. Loaʻa iā ia ka helu transdermal absorption maikaʻi loa, lōʻihi ka noho ʻana a me ke kūpaʻa maikaʻi i ka wahi i hoʻopaʻa ʻia i ka ʻili. Loaʻa iā ia nā kumukūʻai haʻahaʻa a me nā noi efficacy kiʻekiʻe ma ke kahua o nā mea hoʻonaninani, nā meaʻai hana a me nā lāʻau lapaʻau.

ʻenehana hoʻohuihui ponoʻī ʻo Peptide hierarchical

Nā hiʻohiʻona ʻenehana: ʻo ka ʻoihana mua, ka hoʻoponopono i manaʻo ʻia o ka hoʻolālā multilevel o nā kaulahao amino acid a me nā polypeptides, nā peptides pōkole i hui pū ʻia, nā polypeptides supramolecular

Aʻoaʻo ʻenehana: E hoʻomaikaʻi i ka amphiphilicity, hoʻomaikaʻi i ke kūpaʻa a me ke kū ʻana o ka wela, e hōʻemi i ka ʻona a me ke koʻikoʻi kūlohelohe, hoʻoikaika i ka absorption, a synergize.

Nā laʻana o nā mea ʻai: supramolecular carnosine, yeast protein peptide

ʻO ka hui pū ʻana o nā protein a me nā peptides ʻaʻole ia wale nō i nā ʻōnaehana ola, akā he waiwai endogenous maikaʻi nō hoʻi no ke kino o ke kanaka, a ʻo kekahi o nā ala kūpono no ka synthesizing nano-biological material. ʻO ka peptide self-assembly process he hierarchical assembly process, a ʻo ka "polar amino acid zipper structure" he ʻano hou o ka super-secondary structure, i kūpono i ka hui hierarchical o nā peptides e hana i nā aggregates i kauoha ʻia.

Hiki ke hoʻokō ʻia ka hoʻoponopono kuhikuhi o ka nui o nā peptides pōkole ma o ka hoʻololi ʻana i ka hydrophobicity a me ke kaulahao ʻaoʻao o nā koena hydrophobic.

Ma muli o kā Shinehigh Innovation's unique ProteinDataBank (PDB) database, e hui me ka systematic experimental observation, molecular dynamics and quantum chemistry calculations e kālailai i ke ano o ka peptide molecules, a laila e hoohalike ia lakou me ka high-throughput self-assembly molecules. hiki i ka mole ke hoʻohui iā ia iho. ʻO ka peptide i hui pū ʻia he amphiphilicity maikaʻi loa a me ka symmetry, kahi e hoʻomaikaʻi nui ai i ka paʻa peptide, hiki ke transdermal a me ka bioavailability.